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The FDA approved Rasonque (daraxonrasib) in late August for pancreatic ductal adenocarcinoma after at least one prior therapy. In a 500-person trial, median survival was 13.2 months versus 6.7 on chemotherapy. About 90% of pancreatic cancers carry RAS mutations, which this first-in-class RAS(ON) inhibitor targets broadly. A phase III frontline trial is underway.
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